2021.09.16 17:43 YakushiART Aniversary, do all Brave banners get rerun along with a spark ?
I was just curious . I would like to spark for alm / celica , but the current B!Alm banner doesnt have the summoning rate I would want, nor does it have a spark.
submitted by YakushiART to FireEmblemHeroes [link] [comments]
2021.09.16 17:43 DifficultClothes2122 What do you think?
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2021.09.16 17:43 Snoo_69934 [Ps4/Ps5]H:AA/25/+A Railway Rifle W:Highest cap offer
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2021.09.16 17:43 Loulou_92 David Austin Gardens in Shropshire.
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2021.09.16 17:43 N_Lotus Caught
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2021.09.16 17:43 Broiled_Fish_980 China formally applies to join Pacific Rim trade pact abandoned by the US
2021.09.16 17:43 LELEblork Pls inform me (spoilers from pretty early in the game right after hornet i guess.)
So I'm pretty new to hollow knight and I'm just now playing through it. I have however watched a lore video before (I think from fireb0rn). When i got the hunters journal i was just scrolling through out of curiosity. I saw that in the description of shade it says something along the lines of: 'Each of us leaves one behind when we die.' (picture included below). However i thought that only the vessels had the shade void thingy in them. Does this mean that the hunter is also one of them or am I just missing something?
Thank you in advance for clarifying :)
submitted by LELEblork to HollowKnight [link] [comments]
2021.09.16 17:43 MeliodasPro500 Similar sound.
2021.09.16 17:43 drawingbeybladeburst You thought it was Kirby, but is was me, Dio! For u/Fluffy_Memory_6238
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2021.09.16 17:43 onlydaniccus Starwind Star Wars Morrowind Total Conversion Mod First Impression / Exp...
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2021.09.16 17:43 Footynarrative Laziest streaming company on the planet
I’ve noticed a lot of half arsedness from DAZN this season.
They don’t do matchday highlights package for Champions League anymore looks like, barely show EFL championship matches/individual match highlights/weekly matchday highlights (they’re still stuck on match day 4), and don’t do MLS weekly matchday highlights anymore.
What exactly are we paying for? Just premier league?
submitted by Footynarrative to dazn_ca [link] [comments]
2021.09.16 17:43 RockerSci study presents evidence Alzheimer’s disease begins in the liver
*posted for relevance to livecholesterol discussion - not necessarily directly related to keto. Would be interesting to see how hepatic amyloid production correlates with other liver functions.
An impressive new study is presenting robust evidence showing the toxic proteins thought to be the cause of Alzheimer’s disease may be produced in the liver and travel through the blood before landing in the brain causing neuron damage.
For several decades it has been generally accepted that Alzheimer’s disease is caused by the accumulation of amyloid proteins in the brain. These proteins form toxic aggregations known as plaques and it is these plaques that damage the brain.
Although doubts are growing regarding the veracity of the “amyloid hypothesis,” the build up of these plaques is still the most prominent physiological sign of Alzheimer’s. And one of the more interesting hypotheses going around suggests these damaging amyloid proteins originate in the liver.
The big challenge in investigating this liver-amyloid hypothesis is that amyloid is also produced in the brain. Most mouse models used in Alzheimer’s research involve engineering the animals to overexpress amyloid production in the central nervous system, which only really resembles the minority of humans suffering from hereditary early-onset Alzheimer’s. The vast majority of people developing the disease instead experience what is known as sporadic Alzheimer’s, where the disease develops in older age, with no familial or genetic history.
The breakthrough in this new research is the development of a new animal model of Alzheimer’s disease. Here, the researchers engineered a mouse to produce human amyloid proteins solely in the liver, and this allowed for novel observations into how these proteins can enter the bloodstream and travel to the brain.
John Mamo, lead researcher on the project from Curtin University in Australia, says this new study offers clear evidence of a “blood-to-brain pathway.” Using the newly developed mouse model the study shows how amyloid produced in the liver can move to the brain and cause damage leading to pathological signs similar to those seen with Alzheimer’s disease.
“As we predicted, the study found that mouse models producing lipoprotein-amyloid in the liver suffered inflammation in the brain, accelerated brain cell death and memory loss,” says Mamo. “This ‘blood-to-brain pathway’ is significant because if we can manage the levels in blood of lipoprotein-amyloid and prevent their leakage into the brain, this opens up potential new treatments to prevent Alzheimer’s disease and slow memory loss.”
Mamo is already moving ahead with a human clinical trial based on this liver-amyloid hypothesis. Prior studies have shown a pre-existing drug used to manage high cholesterol, known as probucol, can suppress production of amyloid in the liver.
The clinical trial began this year and plans to recruit around 300 subjects with mild Alzheimer’s-related dementia. The primary outcome will be to investigate whether daily doses of probucol for two years leads to a clinically significant slowing of cognitive decline.
But if this liver-amyloid hypothesis is further validated in future studies a number of other outcomes could arise. Alzheimer’s disease risk may be estimated at a young age by evaluating an individual’s propensity for synthesizing amyloid in the liver. Plus, dietary interventions could hypothetically be deployed to improve liver health and decrease a person’s risk of developing Alzheimer’s.
“While further studies are now needed, this finding shows the abundance of these toxic protein deposits in the blood could potentially be addressed through a person’s diet and some drugs that could specifically target lipoprotein amyloid, therefore reducing their risk or slowing the progression of Alzheimer’s disease,” says Mamo.
The new research was published in the journal PLOS Biology.
Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype
2021.09.16 17:43 CryptoVines 🌱Plant Token🌱 Crypto Job Marketplace🏪 Integrated Chainlink VRF Lottery🎲 Doxxed dev✅ Charity focused use case token☀️
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submitted by CryptoVines to CryptoMars [link] [comments]
2021.09.16 17:43 stradivariuslife Flying to Europe
What is the experience like flying to Europe from the US right now? My wife and I are headed to Munich via BNA-DTW-AMS-MUN with the last leg being KLM. Seems like Delta is running everything through Schipol right now and letting KLM handle the final leg. During normal times we could get a direct from ATL-MUN.
We're vaccinated, which is the only requirement for entry to Germany (as of today) but planning to bring negative PCR tests in case the rules change on us. We've also filled out the passenger locator form that Germany requires and uploaded the vaccine cards. Are they going to be checking all this paperwork every step of the way or have I over-prepared? Just trying to avoid any surprises.
submitted by stradivariuslife to delta [link] [comments]
2021.09.16 17:43 jay_ebooks If you're going to trigger someone with an ED, maybe at least have it make any actual sense.
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2021.09.16 17:43 WearAMaskDumbass Of course I (6'4'') ran into a height clearance sign in the parking garage. Thanks universe.
2021.09.16 17:43 Ultimakey Anyone feel the urge to reapply for a new country?
Checking the Covid-19 vaccination statistics for the country I interviewed for (Tanzania) is so disheartening. It took a month to vaccinate 0.9% of the population. Then, I look at countries like the Dominican Republic and Peru, and see that they both have over 30% of their citizens vaccinated. Things aren’t looking up for a lot of African countries because of the widespread misinformation confusing the people. Anyone ever just feel like re-applying to aim for a country that will most likely leave sooner? I’m not keen on waiting til 2024 because my country is going o be behind on vaccinations until then.
submitted by Ultimakey to peacecorps [link] [comments]
2021.09.16 17:43 Cetsril Dayılar yardım lazım
Şimdi ben arkadaşlarla bi idiaaya girdim, okulun en güzel kızını kendime ayarlarım dedim. Normalade yaparım lakin hiç bir ortak noktamız yok. Üstüne üstlük o benden bir sınıf büyük. Sınıfı hemen bizim sınıfımızın yanında ve koridorda hep karşılaşıyoruz. Sınıfından kimseyle konuşmuşluğum yok. Kendisi voleybolda okulumuzu temsil ediyor. Anlayacağınız kız benim bir üst ligim ancak imaknsız olduğunu düşünmüyorum. Neyse beyler, ben bunu nasıl sikerim?
submitted by Cetsril to KGBTR [link] [comments]
2021.09.16 17:43 tequilasky Germany averted possible attack on synagogue during Yom Kippur, minister says
2021.09.16 17:43 JosephMallozzi Lorak's alien camera (concept) ' "The Light"
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2021.09.16 17:43 kovacic93 Math problem, different result but right formula?
Got stuck on a problem. Any help much appreciated. let’s say I have a population of 10k and from those 10k, 7k are employed. Do i have to do something like (people employed 7k)/(tot no of population)*100? Cause I’m doing this with different numbers, but the result doesn’t come up.
submitted by kovacic93 to cheatatmathhomework [link] [comments]
2021.09.16 17:43 Violinist_inProgress I learned something about a few US states...
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2021.09.16 17:43 TrendingBot [Mildly Trending] /r/spacefrogs - SPACE FROGS (+201 subscribers today; 379% trend score)
2021.09.16 17:43 L1me-E Hyviä nimiehdotuksia ryhmälle
2021.09.16 17:43 Impossible-Antelope9 Comforting dream
Had a dream I was in McDonald’s with my granny and poppy. They both died recently in their 90s. Granny was shocked I was there but it felt normal to me and I was about to order them both McDonald’s. I never got to finish buying it for them. Kinda funny the role reversal because of all those times in childhood they bought me McDonald’s. Last thing I remember saying “and what would poppy like?”
submitted by Impossible-Antelope9 to Dreams [link] [comments]